Wide Pore Hydrophillic Anion Exchange Resins

Mitsubishi Chemical has launched a new series of wide pore ion exchange resins, called ChromSpeedTM, for high performance protein and antibody separations. These resins are based on mono-dispersed high crosslinked polymethacrylic matrix, with a hydrophilic layer to achieve high throughput purification without surface interaction with the resin surface. The below methacrylic matrices are functionalized with either a quaternary amine (trimethyl amine) or a diethyl-aminoethyl to form strong basic and weak basic anion exchangers respectively with a chloride counter ion. These resins are easily scalable and non-compressible (rigid) with no volume change in buffer exchange. They are also characterized by their high capacity for polyclonal IgG. See below for our new anion exchange offering.

The FP grade resins are based on highly crosslinked polymethacrylic matrix, which is hydroxylated for added hydrophilicity. These matrices are functionalized with either a diethyl-amino, or hexyldiamine to form weak basic anion exchangers.  These resins are used in the large scale separation of anionic proteins, peptides, and polynucleotides (separation ran at a pH > PI of the target molecule) as well as enzyme immobilization supports. These methacrylic matrices have excellent mechanical strength with wide range pH stability (1 to 13) and resistance to high temperatures (up to 60°C operating temperature). FP-DA13 is a unique product to Mitsubishi Chemical.  The diethylamine (DEA) functionality is a secondary amine base group which provides increased capacity towards target molecules.